Maximize Your Clinical Research Potential with the Leading Neuroscience CRO

Regulatory Strategy & Support

Neurology clinical trials face challenges such as navigating evolving regulatory guidelines, obtaining informed consent in vulnerable populations, and defining meaningful endpoints while managing confounders like the placebo response—key factors for compliance and trial success.

As a specialized neuroscience CRO, Allucent collaborates closely with international regulatory agencies to stay informed on the latest requirements and advancements in neuroscience trials for neurological, pain, and psychiatric treatments. This expertise enables us to navigate the complexities of these trials effectively, including:

• Implementation of streamlined regulatory pathways and expedited approvals
• Patient-centric approaches
• Use of biomarkers and surrogate endpoints.

Study Design

Neurology clinical trials and psychiatric clinical trials present a wide range of complex design challenges, from assessing brain penetration for translational PK/PD in dose selection to managing high placebo response in psychiatric and pain indications, necessitating rigorous training and control measures. Neuroscience trials often require multiple subjective assessment scales, demanding standardized and extensive rater training. Additionally, the increasing use of invasive drug administration, fluid biomarker sampling, and specialized imaging further complicates trial execution and design.

As a specialized neuroscience CRO, Allucent brings together clinical pharmacology experts, regulatory strategists, biostatistical consultants, and medical affairs professionals to provide robust and efficient study design recommendations. From first-in-human neurological and psychiatric studies to pivotal trials, our CNS CRO expertise ensures the development of appropriate and clinically meaningful endpoints, dose optimization, and placebo response management. We also support long-term follow-up to maximize the quality and impact of neuroscience clinical research, ultimately leading to better patient outcomes and more effective treatments.

Site Networks

As a leading neuroscience CRO, Allucent has established relationships with site and hospital networks worldwide, bringing extensive expertise in conducting neurology clinical trials and psychiatric clinical trials across all phases of development. Our site networks are equipped to handle complex study requirements, including advanced neuroimaging and neurophysiological monitoring. Partnering with a leading CNS CRO such as Allucent, and collaborating with skilled radiologists and neuroimaging specialists, we deliver high-quality image acquisition, interpretation, and protocol development to support seamless trial execution and reliable data outcomes for neuroscience clinical research.

Patient Recruitment & Retention

Ensuring diverse, representative patient populations in neuroscience trials is essential for regulatory compliance but often presents challenges in patient recruitment, particularly for neurology clinical trials and psychiatric clinical trials involving rare neurological conditions. Additionally, many of these trials require prolonged follow-up periods, which can lead to patient dropout over time.

As a leading neuroscience CRO, Allucent’s Dedicated Patient Engagement Team provides tailored strategies to enhance patient recruitment, consent, engagement, diversity, and compliance across neurological, pain, and psychiatric conditions. By collaborating with a leading neurology CRO, like Allucent, we leverage on-site, decentralized, and hybrid trial designs—including DCT approaches—to make patient participation more accessible and less burdensome. We utilize remote assessments, wearables, eCOAs, reliable caregivers, and our extensive CNS CRO site networks to optimize recruitment and retention strategies, ultimately improving the success of neuroscience trials.

Preferred Partners

As a leading neuroscience CRO, Allucent has established a network of industry-leading preferred partners that provide advanced technology solutions to enhance the design, implementation, and management of neuroscience trials. Our collaborations support critical aspects of trial execution, ensuring high-quality data and streamlined processes.

These solutions include:

• EEG
• Neuroimaging (MRI, fMRI, PET, CT) acquisition and centralized reading
• ePRO & eCOA (including rater scales and training)
• Entry/exit interviews
• Wearables
• Fluid biomarkers
• Cognitive batteries

Leveraging our extensive partner network and collaborating with a trusted CNS CRO, we ensure efficient collaboration, enhance patient safety, and deliver exceptional data quality for neurology and psychiatric clinical trials.